Page 170 - Pharm.Org.Chem-I 02-06-05-101
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How Do Substituents Affect Reactivity?
If the substituent is an
Electron Donating Group
It makes the ring more electron rich
The ring will be more reactive
towards the electrophile
The reaction will take place faster.
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How Do Substituents Affect Reactivity?
If the substituent is an
Electron withdrawing Group
It makes the ring electron poor
The ring will be less reactive
towards the electrophile
The ring reacts with the
electrophile slowly
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