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4- Deactivating o, p- orienting groups:
e.g. Halogens (F, Cl, Br, I)
-I > +R
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o- , p- orienting groups
Classification Example Effect
1- Very strongly NH2, -NHR, -NR2, -OH, O- + R >> -I
activating NHCOR, OCOR, OR
+ R > -I
2-Moderatly activating R (CH3, C2H5, ....) , phenyl
3- Weakly activating +I effect and
hyperconjugation
4- Deactivating halogens: F, Cl, Br, I -I > +R
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