Page 305 - Biochemistry PharmD General
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Pancreatic Colipase
-Colipase is a protein co-enzyme that is required for optimal
activity of pancreatic lipase.
-Secreted by the pancreas in its inactive form and activated by
trypsin in the duodenum.
-It prevents the bile salts from inhibiting lipase actions.
-Works by binding to the C-terminal domain, thus stabilizing the
active conformation and increasing the hydrophobicity of the
binding site.
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