Page 309 - Biochemistry PharmD General
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Cholesterol Biosynthesis Pathway
The process to form the 27 carbon compound of
cholesterol occurs primarily in 4 main stages.
Stage 1: Synthesis of mevalonate from acetate
Two molecules of acetyl-CoA condense, forming
acetoacetyl-CoA, which condenses with a third
molecule of acetyl-CoA to yield the six-carbon
compound β-hydroxy-β-methylglutaryl-CoA
(HMG-CoA), which is then reduced to form
mevalonate.
Generally takes place in the endoplasmic reticulum of hepatic cells!
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