Page 80 - Biochemistry PharmD General
P. 80
Glucose action in the b-cell
Glucose enters the b-cell as
blood glucose concentration
rises. Glycolysis to generate
ATP closes K+ channels in
the cell membrane, stopping
outward transport, and
opening Ca+ channels.
Inward flux of Ca+ causes
exocytosis of insulin-
containing secretory
vesicles. Glucose also
stimulates synthesis of new
insulin.
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