Page 85 - Biochemistry PharmD General
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1- Hormonal Regulation
• Insulin stimulates synthesis of all key enzymes of
glycolysis. It is secreted after meal (in response to
high glucose level).
• Glucagon inhibits activity of all key enzymes of
glycolysis. It is secreted in starvation (in response to
low glucose level).
2- Energy Regulation
• High level of ATP inhibits PFK-1 and Pyruvate kinase.
• High level of ADP,AMP stimulates PFK-1.
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