Page 93 - Biochemistry PharmD General

Clinical Aspects of Glycolysis

1- Pyruvate kinase deficiency:

• This leads to excessive hemolysis of RBCs leading to
hemolytic anemia.

• Genetic deficiency of PK leads to decrease in rate of
glycolysis and decrease production of ATP. ATP is
required for Na-K ATPase which is important for the
stability of RBCs.

2- Hexokinase deficiency:

• Similar mechanism as PK 92