Page 12 - controlled drug delievery

1- Aqueous Solubility & Ionization
constant

The rate of drug release from MR delivery system is controlled by
one or more of 2 basic mechanisms: Dissolution and/or
diffusion; both processes are highly dependent on the aqueous
solubility of the drug.

Insoluble OR slowly soluble polymer matrix

Drug
reservoir

Insoluble OR slowly soluble polymeric
membrane