Page 29 - controlled drug delievery
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Cont. 1-A- Diffusion controlled-Reservoir type
Single unit systems
Core formulation:
1. Active drug
2. Filler: Lactose, sucrose, manitol, sorbitol, xylitol.
3. Lubricant/glidant; Mg stearate, colloidal silicon
dioxide.
4. Solubilizers: buffers, surfactants, polyols.
Coat formulation:
1. Membrane polymer e.g. Ethyl cellulose, acrylate
polymers (Eudragit RL &Eudragit RS), Zein
2. Plasticizer e.g. Dibutyl phthalate, PEGs, glycerol
3. Membrane modifiers e.g. PEGs, glycerol,
propylene glycol
