Page 35 - controlled drug delievery
P. 35
Characteristics of reservoir diffusional
systems
1. Drug core is surrounded by water insoluble membrane that
controls the drug release.
2. Zero order delivery is possible
3. Release rate variable with --------------------
4. Diadvantages:
1. Difficult to deliver high molecular weight drugs.
2. Potential toxicity if the system fails.
3. Systems must be surgically removed (in case of subcutaneous
implants).