Page 72 - controlled drug delievery

Drug targeting levels

• Organ targeting

– Brain targeting for treatment of Alzheimer’s or Parkinson’s
disease

• Targeting to specific tissues

– Solid tumours or inflammation sites.

• Cytosolic targets (across the cell membrane)

– Targeting cytoplasmic receptors e.g. glucocorticoid receptors.

• Subcellular compartments

– Targeting DNA by intercalating agents e.g. doxorubicin
– Nuclear targeting in gene therapy applications.

• Invading organisms

– Bactria, viruses, parasites e.g. Tuberclosis, HIV & malaria
respectively.