Page 67 - controlled drug delievery

Transdermal drug delivery systems (TTSs)

Disadvantages of TDDS

1. Drug solubility?
2. Drug potency?
3. Skin reaction may result from prolonged contact with the

drug or system components.
4. Side effect (e.g. nicotine patches) or tolerance (e.g. glyceryl

trinitrate patches) may develop with patches applied
around 24 h period.