Page 63 - controlled drug delievery

Parenteral controlled release DDS

long acting injectables?

E.g. Lupron® depot
PLGA microspheres containing luprolide; a
gonadotrophin releasing hormone analogue for
treatment of prostate cancer (4 months release period)

Subcutaneous implants:

Sterile drug loaded polymeric devices which are placed s.c.
to control the dug release via various mechanisms.

i. Biodegradable device

E.g. (Zoladex®)

Cylindrical PLGA implant containing goserelin; a gonadotrophin
releasing hormone analogue for treatment of prostate cancer (1-
3 months release period)