Page 72 - Pharmd general phytochemistry I-Final2024_LEUCTERS

- Glycyrrhizic acid is a β-Glycyrrhitinic acid + two glucuronic acid units

Glycyrrhizic acid
- Glycyrrhizin is the Ca, K & Na salts of Glycyrrhizic acid.

Carbenoxlone is Succinic acid ester of glycyrrhitinic acid
(It is semisynthetic)

Succinic acid

Carbenoxolone

Uses:
Glycyrrhizin is the major active constituent liquorice root and has
been used in traditional medicine for bronchitis, gastritis and jaundice.
Glycyrrhizin was shown to be effective in:
- Gastric ulcer treatment.
- Arthritis and other inflammatory diseases.
(due to its cortisone - like action)
Carbenoxolone is used for the treatment of peptic, esophageal and
oral ulceration and inflammation.
Carbenoxolone is also used as a gel or mouthwash in the treatment of
mouth ulcers. Topical carbenoxolone has antiviral activities,
used to treat oro-facial herpes simplex infections.

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