Page 66 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Control of microbial contamination

The microbiological quality of drugs is necessary for their efficacy and the safety
of the patient

Therefore, control of microbes in drugs is essential, either by

➢ assuring absence of microbes in sterile drugs
➢ by controlling microbial bioburden to appropriate levels for nonsterile
drugs

Sterile products Non-sterile

Sterile compounded medications are Non-sterile medications include the
intended to be used as injections, production of solutions, suspensions,
infusions, or application to the eye ointments, creams, powders,
suppositories, capsules, and tablets.
Terminally sterilized aseptically Controlled environment

manufactured prepared in a clean environment but
without aseptic techniques required

Types of Sterile Processing

Terminal sterilization

• the product being sealed in its container and then sterilized.

• Must be manufactured in a clean area

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