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MANSOURA NATIONAL UNIVERSIY
         PHARM D- CLINICAL PHARMACY                        LEVEL I                        PHARM. ANAL. CHEM. I (PC 101)



          2. Phenolphthalein (ph.ph.):


                 pH range ≈ (8.5 – 10) approximately.

                 We use 10 drops of it in our experiments.


                 Color:
                                         Colorless                     *                 Pink


                   pH   0                                     8.5            10                       14
                                                                                         
                                           Acidic                     E.P.               Basic

                                         to ph.ph.                                   to ph.ph.

               *Color of ph.ph. at E.P.:

               -If the solution before starting titration is Colorless (i.e. acidic to ph.ph.)

                  E.P. is First Pink Color persistent for 30 seconds.

               -If  the  solution  before  starting  titration  is  Pink  (i.e.  basic  to

                 ph.ph.)  E.P. is First Colorless.



             Remember:
          
             ph.ph. (small letters) is phenolphthalein indicator
             while

             pH (p small, H capital) is a measure of acidity or alkalinity { = –log [H ] }
                                                                                                 +


           Question: Complete the following:

             Color of M.O. in water is yellow while color of ph.ph. in water is colorless.


          Example of acid-base reactions:

                                      NaOH  +  HCl    NaCl  +  H 2O
                                         (basic)     (acidic)    (neutral {pH=7})






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