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Xcellerex XDR 50 to 2000 single-use stirred-tank
bioreactors from Cytiva
Xcellerex XDR single-use bioreactor systems provide scalable and robust
stirred-tank performance for up to 2000 L in both cGMP and non-cGMP
environments.
The Xcellerex™XDR bioreactor • Reliable and quantifiable pro- • Process and operational
product line offers the benefits cess performance support from staff with
of single use technology and • Separation of gas and electri- extensive manufacturing
stirred tank design in a modular, cal power for enhanced safety experience
turnkey, bioreactor platform (Fig • Scalable and predictable
1). Designed for scalability and stirred tank performance up
robustness, the XDR bioreactor to 2000 L
systems provide the performance • Single use technology elim-
and flexibility needed from pro- inates costly and time con- Offers
cess development to large scale suming cleaning and cleaning smooth
biopharmaceutical manufactur- validation
ing. XDR bioreactor systems can • Advanced automation and transfer
be operated in batch, fed batch, modular system design to sup- from
and perfusion modes. XDR biore- port a variety of installation
actor systems offer the following scenarios process
benefits: development
to
manufacturing
scale
Supports
batch, fed-batch
and perfusion
System overview
The full line of XDR bioreactor systems are designed and
characterized to deliver scalable process equivalence from 4.5 L to
2000 L working volume, in both GMP and non GMP environments.
The system design is based on the same foundational principles as
conventional stainless steel bioreactors. Consistent vessel
geometries, tight relationship between consumables and
equipment features, and a host of accessories combine for an
easily scalable, single use product line. Traditional scaling method-
ology, based on measures such as shear, tip speed, power per unit
volume, kL a, and specific process sensitivities, can be used during
scale up.
Bioreactor system components: XDR
vessel and X Station mobile control Technology transfer using the XDR systems is straightforward, min-
console imizing the need for costly and time consuming process redesign.
For enhanced utility across the bioreactor platform, the minimum
working
JUNE-2021 39
