Page 105 - Practical Handout bio 2 mnu 2025_Neat
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Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
Renal function testing
(Creatinine)
❖ Creatinine is a breakdown product of creatine
phosphate in muscle.
❖ It is usually produced at a constant rate by the body
(depending on muscle mass).
Source
&
Fate
❖ Healthy kidneys filter creatinine out of the blood into
urine.
Blood level Urine level
Normal
Females 0.5 to 1.0 mg/dl
level 1-3 g/day
Males 0.7 to 1.2 mg/dl
❖ Calculation of the glomerular filtration rate (GFR) as an
important indicator of renal health because it is excreted
from the body entirely by the kidneys.
❖ Creatinine test is ordered for the following reasons:
1. To make a diagnosis if signs or symptoms of kidney
Diagnostic disease are present.
value 2. To screen for kidney disease in patients with diabetes,
high blood pressure, or other conditions that increase the
risk of kidney diseases.
3. To monitor kidney disease treatment or progression.
4. To monitor for side effects of drugs that may include
kidney damage or altered kidney function.
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