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Level two – Semester 4 - PharmD      Biochemistry-II PB-403 (Practical course)     2024/2025


                                5.  To monitor the function of a transplanted kidney.






             Conditions

              with low          1.  Normally in elderly, children and women.

                serum           2.  In muscle wasting diseases.

               levels of        3.   starvation.

             creatinine

                                1.  Black men and women have a higher amount of muscle

                                    mass  than  Caucasians;  hence,  they  have  higher  serum
             Conditions
                                    creatinine levels.
              with high
                                2.  Drugs such as salicylates and cimetidine.
                serum
                                3.  Higher meat intake.
               levels of
                                4.  Exercise.
             creatinine
                                5.  Kidney damage or failure



                                ❖  The  significance  of  a  single  creatinine  value  must  be

                Notes               interpreted considering the patient's muscle mass.

                                ❖  A patient with a greater muscle mass will have a higher


                                    creatinine level.
                                ❖  While  a baseline serum  creatinine  of  2.0 mg/dl  may

                                    indicate normal kidney function in a male bodybuilder, a

                                    serum creatinine of 1.2 mg/dl can indicate significant renal

                                    disease in an elderly female.










                                         Creatinine vs BUN






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