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Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
Liver function tests (Ammonia)
➢ Background:
• Ammonia is produced by the metabolism of amino acids and
other compounds which contain nitrogen.
Ammonia is toxic to the
central nervous system Converted through urea cycle Urea (Less toxic form)
(CNS). in the liver into:
Liver dysfunction cause increased ammonia
level in the blood
(Hyper-ammoinemia).
Definitions
Hepatic Encephalopathy
Neuropsychiatric abnormalities resulting from the accumulation of neurotoxic
substances in the bloodstream and ultimately in the brain due to advanced liver
dysfunction.
Reye’s Syndrome
Rare and fatal pediatric illness defined as acute encephalopathy with liver failure.
The syndrome often begins in the days following recovery from a viral illness during
which aspirin was administered.
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