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Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
➢ Hyperuricemia:
Elevated serum uric acid level.
• Causes:
Purine-rich diet as: meats, certain fish, and
Purine Intake turkey
E.g.: Chemotherapy.
High cell
Leukemia.
breakdown Hemolysis.
E.g.: Acute/chronic kidney disease.
Decreased Use of diuretics (as they are interfering with
renal uric acid excretion).
excretion.
• Consequences:
In hyperuricemia, uric acid (poorly soluble in blood) tends to form
crystals, such crystals precipitate either in:
Joints Kidney
Gouty Nephrolithias
Arthritis is (Kidney
stones)
Big toe is the main
site of precipitation.
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