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Level two – Semester 4 - PharmD      Biochemistry-II PB-403 (Practical course)     2024/2025


                             Measurement of Uric Acid Levels


                 Uric acid is the metabolic end-product of purines (Adenine and

                                            Guanine) metabolism.










                       ➢ Sources and fates of uric acid:





















               Notes:
                                          gh 75% of uric acid is excreted through kidneys
                         Althou

                         and is representative to the renal function, it is not used in
                         practical settings to evaluate renal function.




                       ➢ Normal values:


                         Adult males:                                     Adult females:

                       4.0-8.5 mg/dL                                      2.7-7.2 mg/dL



                 This difference is due to estrogen-related enhancement of renal urate
                                                       clearance.















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