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to full genome equivalence originally provided by mFISH. A comparison between these two measures of
genome-equivalent damage produced some interesting results. For simple exchanges, the “scaled-up”
three-color data matched mFISH data surprisingly well for some types of radiation. However, for overall
damage, which included the contribution made by complex exchanges, large discrepancies occurred that
were both dose- and LET-dependent.
1
(PS6-24) Skin thermal effusivity changes as predictor for radiation exposure. Nrusingh C. Biswal, PhD ;
1
1
1
2
1
Jiangang Sun, PhD ; Zhen Wu, MS ; Damian Bernard, PhD ; James Anderson, PhD ; Virag Dandekar, MD ;
1
1
3
1
Briana J. Jegier, PhD ; Gayle E. Woloschak, PhD ; Katherine L. Griem, PhD ; and James C.H. Chu, PhD , Rush
1
2
University Medical Center, Chicago, IL ; Argonne National Laboratory, Chicago, IL ; and Northwestern
3
University, Chicago, IL
A three-dimensional thermal tomography imaging (3DTT) system has been designed to measure
thermal effusivity changes following radiation exposure. Potential applications include early detection of
skin reactions in cancer patients undergoing radiotherapy or large scale monitoring following a radiation
disaster. The system consists of two high power (5000 W) photographic flash lamps with custom built
infrared (IR) filters and a high performance IR camera. The 3DTT system produces three-dimensional
effusivity images by 1) inducing a brief surface temperature change with flash lamps; 2) measuring the
thermal response of the skin by taking a rapid set of images using the IR camera; and 3) calculating thermal
effusivity-based cross-sectional images using a thermal diffusion model. 4-5 week old female SKH-1
hairless mice were irradiated to different dose levels (20 Gy, 10 Gy, 5 Gy and 2 Gy) to the dorsal surface
of the right hind thigh in a single fraction using a 1.0 cm Leipzig applicator with an Ir-192 radiation source.
Images were obtained 30 minutes pre-irradiation and 0.5 hour, 1 hour, and daily post-irradiation. Circular
regions of interest (ROI) with 1.0 cm diameter were drawn around the irradiated region on 100 slices of
coronal cross-sectional images of approximately 20 µm thick. Mean and standard deviations of apparent
effusivity in these ROIs were calculated for each image. A baseline effusivity reading was obtained from a
plastic phantom placed next to the mice during every measurement. The relative effusivity was computed
as ratios of effusivities from the mouse to that of the phantom. The preliminary data showed 6-12%
change in relative effusivity from 2-20 Gy radiation exposure as early as 30 minutes post-irradiation.
Differences in effusivity were also observed several days post-irradiation. Our preliminary data on skin
effusivity changes following radiation exposure suggest application of 3DTT in early prediction of radiation
exposure. More experiments are warranted to confirm these findings and to extend the study to human
subjects. At present, we are measuring baseline effusivity on healthy human volunteers including different
skin colors and planning to measure radiation-induced effusivity changes on patients scheduled to receive
interventional radiology or radiation therapy procedures.
(PS6-25) Strengthening of biological dosimetry in IAEA member states (Coordinated Reseach Project
2
1
1
E35008, 2012-2016). Oleg V. Belyakov, PhD ; Jan Wondergem, PhD ; and Eduardo Rosenblatt, MD
Section of Applied Radiation Biology and Radiotherapy, International Atomic Energy Agency, Vienna,
1
Austria and Leiden University Medical Center, Leiden, Netherlands
2
The International Atomic Energy Agency (IAEA) started Coordinated Research Project (CRP)
E35008 on Biodosimetry in 2012 following the Fukushima Accident and it will run for four years. The
337 | P a g e
genome-equivalent damage produced some interesting results. For simple exchanges, the “scaled-up”
three-color data matched mFISH data surprisingly well for some types of radiation. However, for overall
damage, which included the contribution made by complex exchanges, large discrepancies occurred that
were both dose- and LET-dependent.
1
(PS6-24) Skin thermal effusivity changes as predictor for radiation exposure. Nrusingh C. Biswal, PhD ;
1
1
1
2
1
Jiangang Sun, PhD ; Zhen Wu, MS ; Damian Bernard, PhD ; James Anderson, PhD ; Virag Dandekar, MD ;
1
1
3
1
Briana J. Jegier, PhD ; Gayle E. Woloschak, PhD ; Katherine L. Griem, PhD ; and James C.H. Chu, PhD , Rush
1
2
University Medical Center, Chicago, IL ; Argonne National Laboratory, Chicago, IL ; and Northwestern
3
University, Chicago, IL
A three-dimensional thermal tomography imaging (3DTT) system has been designed to measure
thermal effusivity changes following radiation exposure. Potential applications include early detection of
skin reactions in cancer patients undergoing radiotherapy or large scale monitoring following a radiation
disaster. The system consists of two high power (5000 W) photographic flash lamps with custom built
infrared (IR) filters and a high performance IR camera. The 3DTT system produces three-dimensional
effusivity images by 1) inducing a brief surface temperature change with flash lamps; 2) measuring the
thermal response of the skin by taking a rapid set of images using the IR camera; and 3) calculating thermal
effusivity-based cross-sectional images using a thermal diffusion model. 4-5 week old female SKH-1
hairless mice were irradiated to different dose levels (20 Gy, 10 Gy, 5 Gy and 2 Gy) to the dorsal surface
of the right hind thigh in a single fraction using a 1.0 cm Leipzig applicator with an Ir-192 radiation source.
Images were obtained 30 minutes pre-irradiation and 0.5 hour, 1 hour, and daily post-irradiation. Circular
regions of interest (ROI) with 1.0 cm diameter were drawn around the irradiated region on 100 slices of
coronal cross-sectional images of approximately 20 µm thick. Mean and standard deviations of apparent
effusivity in these ROIs were calculated for each image. A baseline effusivity reading was obtained from a
plastic phantom placed next to the mice during every measurement. The relative effusivity was computed
as ratios of effusivities from the mouse to that of the phantom. The preliminary data showed 6-12%
change in relative effusivity from 2-20 Gy radiation exposure as early as 30 minutes post-irradiation.
Differences in effusivity were also observed several days post-irradiation. Our preliminary data on skin
effusivity changes following radiation exposure suggest application of 3DTT in early prediction of radiation
exposure. More experiments are warranted to confirm these findings and to extend the study to human
subjects. At present, we are measuring baseline effusivity on healthy human volunteers including different
skin colors and planning to measure radiation-induced effusivity changes on patients scheduled to receive
interventional radiology or radiation therapy procedures.
(PS6-25) Strengthening of biological dosimetry in IAEA member states (Coordinated Reseach Project
2
1
1
E35008, 2012-2016). Oleg V. Belyakov, PhD ; Jan Wondergem, PhD ; and Eduardo Rosenblatt, MD
Section of Applied Radiation Biology and Radiotherapy, International Atomic Energy Agency, Vienna,
1
Austria and Leiden University Medical Center, Leiden, Netherlands
2
The International Atomic Energy Agency (IAEA) started Coordinated Research Project (CRP)
E35008 on Biodosimetry in 2012 following the Fukushima Accident and it will run for four years. The
337 | P a g e
