Page 388 - 2014 Printable Abstract Book
P. 388
(SNA 02) EU project 'CEREBRAD' Cognitive and Cerebrovascular Effects Induced by Low Dose Ionizing
Radiation. Rafi Benotmane, SCK•CEN, Mol, Belgium
CEREBRAD, Cognitive and Cerebrovascular Effects Induced by Low Dose Ionizing Radiation, is a
collaborative European project funded in 2011 within the 7th EU framework programme of EURATOM,
Nuclear Fission and Radiation Protection. CEREBRAD aims to identify the potential cognitive and
cerebrovascular risks of radiation doses below 100 mGy when delivered to a young child (pre- or
postnatally). The CEREBRAD project contains 3 RTD work packages that are interrelated to understand the
effect of low dose ionizing radiation (LD-IR) at different stages of brain development especially on the
induction of cognitive and/or cerebrovascular diseases. The first RTD work package (WP2) concerns the
collection and analysis of human data. WP2 is dedicated to increase the statistical power of
epidemiological data on cognitive and cerebrovascular diseases following low-dose exposures. Health
risks are assessed via epidemiological studies of patients exposed in their young age to radiotherapy
treatment and receiving low doses to the brain as well as of children born within one year after the
Chernobyl accident. The scope of the second RTD work package (WP3) is to gather complimentary data
about cognitive and cerebrovascular effects using animal models exposed to radiation at different stages
of brain development. Emphasis is put on the effects of internal and external exposures, as well as the
combined effect of radiation and environmental pollutants. The third RTD work package on mechanistic
analyses is handled in WP4. In this work package, the intimate mechanisms activated by LD-IR in the brain
are investigated. Profound alterations occur in biological pathways responsible for neuronal maturation
and differentiation. In addition, LD-IR induces neuro-inflammation and robust glial activation, impairing
neurogenesis, and perturbing the oxido-reductive equilibrium in neurons. All together, the mechanistic
interplay of early and late effects will be illustrated via integrated cellular and molecular analyses to
decipher the metabolic pathways and regulatory networks underlying the cognitive and cerebrovascular
effects induced by low dose radiation. Thus, CEREBRAD outcomes would reduce the uncertainty about
non-cancer effects and improve the risk estimates and protection measures of the fetus in utero and
during childhood. Acknowledgements: This project is supported by the EU-FP7 project CEREBRAD
(n°295552)
(SNA 03) Project PROCARDIO, Cardiovascular Risk from Exposure to Low-Dose and Low-dose-Rate
Ionizing Radiation. Soile Tapio, Helmholtz Centre Munich, Neuherberg, Germany
The study of cardiovascular effects is gaining greater impact amongst the radiation protection
community following the publication of a number of epidemiological studies confirming an increased risk
of cardiovascular disease at medium and high doses. The PROCARDIO consortium will challenge the
hypothesis that there is no long-term health detriment resulting from damage to cardiovascular function
exposed to low doses of ionizing radiation (below 100 mGy) To do this PROCARDIO has established a
consortium to create the first international platform for the study of radiation- induced cardiovascular
disease after low-dose radiation exposure. The PROCARDIO consortium consists of 12 participating
institutions based in eight different EU member states as well as one partner in Russia. The project deals
with investigating the link between cardiovascular disease and exposure of the heart and major vessels at
lower doses to identify new biomarkers of radiation-induced cardiovascular disease. Within the project
cardiovascular dosimetry data will be collected from four cohorts of survivors of childhood cancer
radiotherapy. Both animal and in vitro models will be used to identify molecular biomarkers informing on
Radiation. Rafi Benotmane, SCK•CEN, Mol, Belgium
CEREBRAD, Cognitive and Cerebrovascular Effects Induced by Low Dose Ionizing Radiation, is a
collaborative European project funded in 2011 within the 7th EU framework programme of EURATOM,
Nuclear Fission and Radiation Protection. CEREBRAD aims to identify the potential cognitive and
cerebrovascular risks of radiation doses below 100 mGy when delivered to a young child (pre- or
postnatally). The CEREBRAD project contains 3 RTD work packages that are interrelated to understand the
effect of low dose ionizing radiation (LD-IR) at different stages of brain development especially on the
induction of cognitive and/or cerebrovascular diseases. The first RTD work package (WP2) concerns the
collection and analysis of human data. WP2 is dedicated to increase the statistical power of
epidemiological data on cognitive and cerebrovascular diseases following low-dose exposures. Health
risks are assessed via epidemiological studies of patients exposed in their young age to radiotherapy
treatment and receiving low doses to the brain as well as of children born within one year after the
Chernobyl accident. The scope of the second RTD work package (WP3) is to gather complimentary data
about cognitive and cerebrovascular effects using animal models exposed to radiation at different stages
of brain development. Emphasis is put on the effects of internal and external exposures, as well as the
combined effect of radiation and environmental pollutants. The third RTD work package on mechanistic
analyses is handled in WP4. In this work package, the intimate mechanisms activated by LD-IR in the brain
are investigated. Profound alterations occur in biological pathways responsible for neuronal maturation
and differentiation. In addition, LD-IR induces neuro-inflammation and robust glial activation, impairing
neurogenesis, and perturbing the oxido-reductive equilibrium in neurons. All together, the mechanistic
interplay of early and late effects will be illustrated via integrated cellular and molecular analyses to
decipher the metabolic pathways and regulatory networks underlying the cognitive and cerebrovascular
effects induced by low dose radiation. Thus, CEREBRAD outcomes would reduce the uncertainty about
non-cancer effects and improve the risk estimates and protection measures of the fetus in utero and
during childhood. Acknowledgements: This project is supported by the EU-FP7 project CEREBRAD
(n°295552)
(SNA 03) Project PROCARDIO, Cardiovascular Risk from Exposure to Low-Dose and Low-dose-Rate
Ionizing Radiation. Soile Tapio, Helmholtz Centre Munich, Neuherberg, Germany
The study of cardiovascular effects is gaining greater impact amongst the radiation protection
community following the publication of a number of epidemiological studies confirming an increased risk
of cardiovascular disease at medium and high doses. The PROCARDIO consortium will challenge the
hypothesis that there is no long-term health detriment resulting from damage to cardiovascular function
exposed to low doses of ionizing radiation (below 100 mGy) To do this PROCARDIO has established a
consortium to create the first international platform for the study of radiation- induced cardiovascular
disease after low-dose radiation exposure. The PROCARDIO consortium consists of 12 participating
institutions based in eight different EU member states as well as one partner in Russia. The project deals
with investigating the link between cardiovascular disease and exposure of the heart and major vessels at
lower doses to identify new biomarkers of radiation-induced cardiovascular disease. Within the project
cardiovascular dosimetry data will be collected from four cohorts of survivors of childhood cancer
radiotherapy. Both animal and in vitro models will be used to identify molecular biomarkers informing on
