Page 387 - 2014 Printable Abstract Book
P. 387
SNA. RADIATION-INDUCED LONG TERM NON-CANCER RISKS: EU PROJECTS ‘CEREBRAD’ AND
‘PROCARDIO’
Recent epidemiological studies indicate that exposure to ionizing radiation enhances the risk of cardio-
and cerebrovascular mortality in a significant manner. The aim of our research is to investigate the
pathogenesis of radiation-induced cardio- and cerebrovascular disease using epidemiological, biological
and mathematical modeling tools.
(SNA 01) Epidemiology in EU project 'CerebRad' and ‘ProCardio.” Florent de Vathaire, Epidemiology and
Population Health Research Center, Gustave Roussy, France
Childhood cancer survivors having been treated by radiation therapy are the population the most
at risk of cardiac and cerebrovascular radiation induced diseases. It is crucial to establish reliable dose-
response for radiation dose because this will permit both to anticipate cardiovascular risk in yet treated
patients, and to propose preventive actions, but also to better anticipate the risk induced by new radiation
therapy technics. To estimate the role of radiation in the risk of such disease needs not only a dose
reconstruction of good quality but also to take into account chemotherapeutic drugs, such as
anthracyclines, which are strongly cardiotoxic. The dose response between the radiation dose received to
the heart (ProCardio) and to the Brain (CerebRad) during the treatment of the childhood cancer and of its
relapse and the risk of cardiac (ProCardio) and cerebrovascular pathologies (CerebRad) will be
investigated in case-control studies nested in childhood cancer survivor’s cohorts. 300 cardiac diseases
from UK, Spain and France (ProCardio), and 125 cerebrovascular diseases from UK and Spain (CerebRad)
will be included and individually matched to a control. The methodology and matching criteria are similar
in the 2 studies. The radiation dose the heart, the brain, and other organs of interest of cases and controls
will estimated using a new software developed at Gustave Roussy, which allow to estimate the
distribution of radiation dose in thousands of voxels in each of these organs, using anthropomorphic
phantoms built from real patients in cancer treatment position. In CerebRad, cognitive effects induced by
low dose ionizing radiation, are also evaluated in patients exposed in their young age to radiotherapy
treatment for a skin hemangioma and in Ukrainian subjects having received low doses to the brain in utero
and born within one year after the Chernobyl accident. Acknowledgements: This project is supported by
the EU-FP7 project CEREBRAD (n°295552) and ProCardio (n°295823).
‘PROCARDIO’
Recent epidemiological studies indicate that exposure to ionizing radiation enhances the risk of cardio-
and cerebrovascular mortality in a significant manner. The aim of our research is to investigate the
pathogenesis of radiation-induced cardio- and cerebrovascular disease using epidemiological, biological
and mathematical modeling tools.
(SNA 01) Epidemiology in EU project 'CerebRad' and ‘ProCardio.” Florent de Vathaire, Epidemiology and
Population Health Research Center, Gustave Roussy, France
Childhood cancer survivors having been treated by radiation therapy are the population the most
at risk of cardiac and cerebrovascular radiation induced diseases. It is crucial to establish reliable dose-
response for radiation dose because this will permit both to anticipate cardiovascular risk in yet treated
patients, and to propose preventive actions, but also to better anticipate the risk induced by new radiation
therapy technics. To estimate the role of radiation in the risk of such disease needs not only a dose
reconstruction of good quality but also to take into account chemotherapeutic drugs, such as
anthracyclines, which are strongly cardiotoxic. The dose response between the radiation dose received to
the heart (ProCardio) and to the Brain (CerebRad) during the treatment of the childhood cancer and of its
relapse and the risk of cardiac (ProCardio) and cerebrovascular pathologies (CerebRad) will be
investigated in case-control studies nested in childhood cancer survivor’s cohorts. 300 cardiac diseases
from UK, Spain and France (ProCardio), and 125 cerebrovascular diseases from UK and Spain (CerebRad)
will be included and individually matched to a control. The methodology and matching criteria are similar
in the 2 studies. The radiation dose the heart, the brain, and other organs of interest of cases and controls
will estimated using a new software developed at Gustave Roussy, which allow to estimate the
distribution of radiation dose in thousands of voxels in each of these organs, using anthropomorphic
phantoms built from real patients in cancer treatment position. In CerebRad, cognitive effects induced by
low dose ionizing radiation, are also evaluated in patients exposed in their young age to radiotherapy
treatment for a skin hemangioma and in Ukrainian subjects having received low doses to the brain in utero
and born within one year after the Chernobyl accident. Acknowledgements: This project is supported by
the EU-FP7 project CEREBRAD (n°295552) and ProCardio (n°295823).
