Page 389 - 2014 Printable Abstract Book
P. 389
the cardiovascular effects of low doses. Also radiation-induced non-targeted cell-cell interactions upon
the heart will be investigated. Mathematical models describing the biological mechanisms of radiation
exposure will be developed using both new and available epidemiological and animal data.
SNB/ S05 SOLID CANCER INCIDENCE AMONG ATOMIC BOMB SURVIVORS, UPDATED ANALYSES
THROUGH 2009 (JOINT CRH-RRS SESSION)
(S501) Solid cancer incidence among atomic bomb survivors: Overview of dosimetry, follow-up, and risk
updates. Eric J. Grant; H. Sugiyama; A V; K. Ozasa; and Rerf-nci Cancer Risk Analysis Group
Radiation Effects Research Foundation, Hiroshim, Japan
The Life Span Study (LSS) of 120,321 atomic bomb survivors is a prospective cohort study with
continuous cancer incidence surveillance since 1958. There have been two comprehensive reports (1994
and 2007) on the risks of solid cancer incidence following radiation exposure. A new report is now ready
for publication and will be introduced in this session. The current data have been updated through 2009
representing 11 additional years of follow-up since the 2007 report. In addition to the longer follow-up
period, a number of comprehensive changes have also been incorporated. They are, the inclusion of
lifestyle data (smoking, drinking, and reproductive factors) collected from mail surveys and clinical
interviews, updated doses, and updated migration coefficients to account for migration of cohort
members into and out of the cancer registries’ catchment areas. The 2009 update contains a total of 3.3
million person-years of follow-up and 24,096 incident cases, which represent roughly an additional 0.5
million person-years and 7,000 additional cancers since the 2007 report. Nearly 38% of the LSS cohort was
alive at the end of 2009. The Dosimetry System 2002 has not been altered, however, survivor input data
used to calculate doses have been reviewed and updated. Changes include restoration of map coordinate
precision that was lost due to memory constraints in early computer systems; corrections for distortion
in WWII-era maps, use of geographical information systems to accurately determine ground distance for
those with detailed shielding drawings; accounting for terrain shielding using digital terrain elevation data
now available for all survivors, at their re-estimated locations. The discussion of results will include the
shape of the dose response, risks at low doses, and the effect of adjusting for smoking, and modification
of the dose response by gender, attained age and age at exposure.
(S502) Incidence of female breast cancer in Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958-
2009. Alina V. Brenner; R Sakata; D. L. Brenner; and Rerf-NCI Cancer Risk Analysis Group Radiation
Epidemiology Branch, Bethesda, MD
We evaluated incidence of female breast cancer in the LSS cohort between 1958 and 2009. With
the additional years of follow-up, the number of breast cancers increased by 49%. In total, there are 1,603
breast cancers among 66,053 women with 2.06 million person-years (PY) of follow-up. Risk analysis is
based on the DS02 dosimetry system using updated survivor location data. We fitted Poisson regression
models to evaluate the magnitude of the radiation-associated risks, the shape of the dose response, and
the variation of radiation risks with age at exposure and attained age. In preliminary analyses, we found
evidence of a strong, significant dose response with an estimated ERR per 1 Gy of 1.03 (95% CI: 0.65-1.47)
4
and EAR per 10 PY Gy of 9.56 (95% CI: 6.73- 12.70). There was no significant evidence for non-linearity in
the heart will be investigated. Mathematical models describing the biological mechanisms of radiation
exposure will be developed using both new and available epidemiological and animal data.
SNB/ S05 SOLID CANCER INCIDENCE AMONG ATOMIC BOMB SURVIVORS, UPDATED ANALYSES
THROUGH 2009 (JOINT CRH-RRS SESSION)
(S501) Solid cancer incidence among atomic bomb survivors: Overview of dosimetry, follow-up, and risk
updates. Eric J. Grant; H. Sugiyama; A V; K. Ozasa; and Rerf-nci Cancer Risk Analysis Group
Radiation Effects Research Foundation, Hiroshim, Japan
The Life Span Study (LSS) of 120,321 atomic bomb survivors is a prospective cohort study with
continuous cancer incidence surveillance since 1958. There have been two comprehensive reports (1994
and 2007) on the risks of solid cancer incidence following radiation exposure. A new report is now ready
for publication and will be introduced in this session. The current data have been updated through 2009
representing 11 additional years of follow-up since the 2007 report. In addition to the longer follow-up
period, a number of comprehensive changes have also been incorporated. They are, the inclusion of
lifestyle data (smoking, drinking, and reproductive factors) collected from mail surveys and clinical
interviews, updated doses, and updated migration coefficients to account for migration of cohort
members into and out of the cancer registries’ catchment areas. The 2009 update contains a total of 3.3
million person-years of follow-up and 24,096 incident cases, which represent roughly an additional 0.5
million person-years and 7,000 additional cancers since the 2007 report. Nearly 38% of the LSS cohort was
alive at the end of 2009. The Dosimetry System 2002 has not been altered, however, survivor input data
used to calculate doses have been reviewed and updated. Changes include restoration of map coordinate
precision that was lost due to memory constraints in early computer systems; corrections for distortion
in WWII-era maps, use of geographical information systems to accurately determine ground distance for
those with detailed shielding drawings; accounting for terrain shielding using digital terrain elevation data
now available for all survivors, at their re-estimated locations. The discussion of results will include the
shape of the dose response, risks at low doses, and the effect of adjusting for smoking, and modification
of the dose response by gender, attained age and age at exposure.
(S502) Incidence of female breast cancer in Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958-
2009. Alina V. Brenner; R Sakata; D. L. Brenner; and Rerf-NCI Cancer Risk Analysis Group Radiation
Epidemiology Branch, Bethesda, MD
We evaluated incidence of female breast cancer in the LSS cohort between 1958 and 2009. With
the additional years of follow-up, the number of breast cancers increased by 49%. In total, there are 1,603
breast cancers among 66,053 women with 2.06 million person-years (PY) of follow-up. Risk analysis is
based on the DS02 dosimetry system using updated survivor location data. We fitted Poisson regression
models to evaluate the magnitude of the radiation-associated risks, the shape of the dose response, and
the variation of radiation risks with age at exposure and attained age. In preliminary analyses, we found
evidence of a strong, significant dose response with an estimated ERR per 1 Gy of 1.03 (95% CI: 0.65-1.47)
4
and EAR per 10 PY Gy of 9.56 (95% CI: 6.73- 12.70). There was no significant evidence for non-linearity in
