Page 406 - 2014 Printable Abstract Book
P. 406
age attained and radiation dose and is associated in the mechanistic model with clonal expansion of cells
carrying early molecular changes e.g. disturbed proliferation. The CLIP2 gene represents a surrogate
marker of genomic instability and de-regulated gene expression is preferentially found in patients exposed
at young age [2]. The role of CLIP2 for radiation-induced genomic instability is explored with mechanistic
models. Risk predictions from standard descriptive models and from mechanistic models based on
molecular data are compared for the UkrAm cohort. 1. Abend M, Pfeiffer RM, Ruf C, Hatch M, Bogdanova
TI, et al. (2012) Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal
tissues following the Chernobyl accident. PLoS One 7: e39103. 2. Hess J, Thomas G, Braselmann H, Bauer
V, Bogdanova T, et al. (2011) Gain of chromosome band 7q11 in papillary thyroid carcinomas of young
patients is associated with exposure to low-dose irradiation. Proc Natl Acad Sci U S A 108: 9595-9600.
(S3004) Thyroid Cancer Risk Following Adult Radiation Exposure. Kiyohiko Mabuchi; Alina Brenner;
Maureen Hatch; Mark Little; Steve Simon; and Martha Linet, National Cancer Institute, Bethesda, MD
A large number of adults are exposed to radiation from medical, occupation and environmental
sources. The Fukushima Daiichi nuclear power plant in 2011 reminded us the possibility that large groups
- including many adults - can be exposed to radioactive iodine and external radiation, and that it is
important to understand the effect of age at exposure on cancer risk over entire age spectrum in order to
develop effective radiation protection standards. While the juvenile thyroid gland is at especially high risk
for developing cancer after radiation exposure, data on thyroid cancer related to adult exposure have
been relatively limited until recently. Cancer incidence data, mostly ecological, from Chernobyl clean-up
workers and other nuclear workers have suggested elevated risk of thyroid cancer following low dose
adult exposure. Most recently, a case-control study of Chernobyl clean-up workers in Belarus, Russia and
Baltic countries conducted by the International Agency for Research on Cancer has shown a significant
radiation risk of thyroid cancer, which appears to be much higher than expected from other studies of
exposed populations. We are currently conducting a pilot study of thyroid cancer in Ukrainian clean-up
workers to address the question regarding the radiation risk following adult exposure. Reviewing the
available literature on adult populations exposed to low and moderate doses from various sources of
radiation, one cannot discount, though not firmly establish, the elevation in risk of thyroid cancer, and
this underscores the need for further research.
(S3005) Mental Health and Psychosocial Support after the Great East Japan Earthquake. Yutaka Kato,
1;2
1
MD, PhD, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan
and Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Universitätsklinik Aachen, Aachen,
2
Germany
Since March 11 2011, citizens of Fukushima prefecture have suffered great adversity four times.
Initially, the Great East Japan Earthquake and the following Tsunami had great impact as “natural
disasters”. Afterwards, the Fukushima Daiichi nuclear disaster forced local residents into evacuations,
later combined with harmful rumors and misinformation, giving rise to continual distress as well as great
overall financial loss. The nuclear power plant accident and succeeding malicious rumors might have been
avoided, at least in part, and thus contributed an added element of “man-made disaster.” As a matter of
fact, the majority of public anxiety and related stress of the refugees originated from these ill-informed
carrying early molecular changes e.g. disturbed proliferation. The CLIP2 gene represents a surrogate
marker of genomic instability and de-regulated gene expression is preferentially found in patients exposed
at young age [2]. The role of CLIP2 for radiation-induced genomic instability is explored with mechanistic
models. Risk predictions from standard descriptive models and from mechanistic models based on
molecular data are compared for the UkrAm cohort. 1. Abend M, Pfeiffer RM, Ruf C, Hatch M, Bogdanova
TI, et al. (2012) Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal
tissues following the Chernobyl accident. PLoS One 7: e39103. 2. Hess J, Thomas G, Braselmann H, Bauer
V, Bogdanova T, et al. (2011) Gain of chromosome band 7q11 in papillary thyroid carcinomas of young
patients is associated with exposure to low-dose irradiation. Proc Natl Acad Sci U S A 108: 9595-9600.
(S3004) Thyroid Cancer Risk Following Adult Radiation Exposure. Kiyohiko Mabuchi; Alina Brenner;
Maureen Hatch; Mark Little; Steve Simon; and Martha Linet, National Cancer Institute, Bethesda, MD
A large number of adults are exposed to radiation from medical, occupation and environmental
sources. The Fukushima Daiichi nuclear power plant in 2011 reminded us the possibility that large groups
- including many adults - can be exposed to radioactive iodine and external radiation, and that it is
important to understand the effect of age at exposure on cancer risk over entire age spectrum in order to
develop effective radiation protection standards. While the juvenile thyroid gland is at especially high risk
for developing cancer after radiation exposure, data on thyroid cancer related to adult exposure have
been relatively limited until recently. Cancer incidence data, mostly ecological, from Chernobyl clean-up
workers and other nuclear workers have suggested elevated risk of thyroid cancer following low dose
adult exposure. Most recently, a case-control study of Chernobyl clean-up workers in Belarus, Russia and
Baltic countries conducted by the International Agency for Research on Cancer has shown a significant
radiation risk of thyroid cancer, which appears to be much higher than expected from other studies of
exposed populations. We are currently conducting a pilot study of thyroid cancer in Ukrainian clean-up
workers to address the question regarding the radiation risk following adult exposure. Reviewing the
available literature on adult populations exposed to low and moderate doses from various sources of
radiation, one cannot discount, though not firmly establish, the elevation in risk of thyroid cancer, and
this underscores the need for further research.
(S3005) Mental Health and Psychosocial Support after the Great East Japan Earthquake. Yutaka Kato,
1;2
1
MD, PhD, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan
and Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Universitätsklinik Aachen, Aachen,
2
Germany
Since March 11 2011, citizens of Fukushima prefecture have suffered great adversity four times.
Initially, the Great East Japan Earthquake and the following Tsunami had great impact as “natural
disasters”. Afterwards, the Fukushima Daiichi nuclear disaster forced local residents into evacuations,
later combined with harmful rumors and misinformation, giving rise to continual distress as well as great
overall financial loss. The nuclear power plant accident and succeeding malicious rumors might have been
avoided, at least in part, and thus contributed an added element of “man-made disaster.” As a matter of
fact, the majority of public anxiety and related stress of the refugees originated from these ill-informed
