Page 105 - Pharmaceutical_Analytical_Chemistry_1_Theoretical_Notes_Level_1
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Mansoura National University
Pharm D-Clinical Pharmacy Program Level 1 Pharm. Anal. Chem. 1 (PC 101)
Applications of Non-aqueous Titrations
Acidimetry Alkalimetry
Samples: Basic drugs such as: Acidic drugs such as:
Ephedrine, Adrenaline, Nalidixic acid, Flurouracil.
Caffeine, Acyclovir.
Solvent: Protogenic solvents such as: Protophilic solvents such
glacial acetic acid as: DMF
Titrant: Perchloric acid HClO 4 Sodium methoxide.
Indicator: Crystal violet Thymol blue
(0.5% in glacial acetic acid) (0.5 % in methanol)
Color change from violet to pink to blue
yellowish green.
End point detection in non-aqueous titrations
1- Visual indicators: e.g. crystal violet or thymol blue
2-Potentiometric titration: by apparatus called potentiometer or pH meter.
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