Page 53 - Mancave Sept 2021.cdr

More about flexible and drooping as well as wrinkles appear. As we When the sebaceous (oil) glands produce too much
sebum, these glands grow excessively which causes
age skin cells devide more slowly, and the middle layer
clogged pores and an inflammatory response is
of the skin, called the dermis, begins to thin. The dermis
is composed of a network of elastin and collagen fibers.
puberty (when the body produces more androgen like
As this network loosens and unravels with time, triggered. Genetics and hormonal changes i.e., at
depressions are created on the skin surface. Aging skin
hormones which cause sebaceous glands to enlarge
Tretinoin is also less able to retain moisture, less efficient in and produce more sebum), are the most common
secreting oil, and slower to heal. All these factors
causes of acne. Follicular hyperkeratinisation occurs
contribute to the development of wrinkles. As the dermis
when the cells of the follicle become cohesive and do
and collagen bundles become thinner and disordered,
which results in creases, fine lines and wrinkles develop. not shed normally on the surface of the skin. This
causes dead skin cells to clump together and pores get
blocked which in turn causes the back up of oil in the
Though Tretinoin (Retinoid) is better known for its use How and why does our skin follicle. Acne causing bacteria thrives in the oily depths
against Acne it is also very effective against the fine What does tretinoin do? of the pores. Sebum inside the pore is turned into fatty
lines and wrinkles caused by aging potentially leaving age? acids by bacteria that proliferate due to the airless
the skin healthier and smoother after treatment. Tretinoin (active ingredient) targets the epidermal cells environment, and inflammation in the nearby skin cells
The major cell type of the epidermis, known as known as suprabasal keratinocytes. It causes a large activates.
In the past we found that the aesthetic industry used Keratinocytes (also known as corneocytes) represents number of basal keratinocytes. This promotes shedding
Retinol instead of Tretinoin. It is only recently, if we look the outermost layer of the skin and make up about 90% of keratinized mature and dead skin cells at the surface The active ingredient Tretinoin, is available in the form of
at the past five to ten years that the latter has been used of the skin cells. They originate in the deepest layer of and leaves the skin looking fresher, smoother and more topical cream and oral tablets where Isotretinoin is the
and prescribed far more. If you wish to use tretinoin the epidermis, the stratum basale and move up to the evenly pigmented. This initial improvement is only seen active ingredient in the tablets. Both Pharmaceutical
based creams your doctor will have to prescribe it first final layer of the skin, the stratum corneum. These cells after 3-4 weeks of treatment, where pigment changes products are available only on prescription from a doctor
as it is a schedule 4 tretinoin based cream. secrete keratin and lipids that provide mechanical are generally seen between 6-8 weeks of treatment with or dermatologist. The tablets are often prescribed for
strength to the skin. Keratinocytes are regularly shed tretinoin. It is only after 3-6 months of using tretinoin that immediate or quicker intense treatment of severe acne
The originator product (tretinoin based cream) that is through skin peeling (desquamation). Desquamation is the renewing of the epidermis is visible. The skin should whereas the creams are used to aid in clearing mild to
available on the South African market, is a synthetic the natural process in which skin cells are created, now look and feel smoother, more robust and healthier. moderate acne.
form of Vitamin A. The FDA approved Tretinoin to be sloughed away, and replaced. This happens on the The collagen budles now have an opportunity to thicken
used against mild to moderate acne (Acne Vulgaris) in outermost layer of the skin called the epidermis. and organise more easily causing the appearance of fine When tretinoin is applied onto the skin surface it allows
1971. After seeing the efficacy towards aging, the lines and wrinkles to be less. Tretinoin improves wrinkle the skin to exfoliate more rapidly. This leads to the
active ingredient has been studied The process of aging increase as the majority of texture, decrease pore size pigmentation and sun expulsion of mature comedones and suppresses the
extensively. If we have a look at the cells (keratinocytes) on the outer layer of the damage. formation of microcomedones. Now, the epidermal pores
significant benefits Vitamin A has on skin (epidermis) become more adhesive are less likely to become blocked, the occurrence of
the skin, then we realise how and don't slough off when it naturally pimples, whiteheads and blackheads are reduced
important it becomes as it increases need to, in order to be replaced with The pathogenises of Acne significantly. The pores are now open due to quicker cell
the cell turnover rate, helps prevent new cells. The skin begins to look turnover. Trapped bacteria and irritants are easily
acne, stimulates collagen tired, dry and uneven. The epidermal Acne is a multifunction inflammatory disease that affects released as cells shed. When the patient uses a tretinoin
production and it minimizes cells on the base now replicate slower the skin's oil glands and hair follicles. The oil based topical cream or isotretinoin based tablet, sebum
wrinkles. By treating the skin with and increases the time the (sebaceous) glands are usually attached to a hair follicle production is better regulated or controlled and future
tretinoin, the complexion of the skin keratinocytes stay on the outermost and produces sebum (oil) which protects and lubricates breakouts are prevented. Tretinoin or isotretinoin based
becomes brighter, and fades layer of the skin. Due to this the skin and hair. When sebum and dead skin cells products also has anti-inflammatory properties which
darker marks as it decreases the pigmentation becomes irregular and become trapped in a hair follicle, it forms a plug called a clears up active acne pustules. These pharmaceutical
melanin under the skin. blotchy in appearance. microcomedo and this causes acne to occur. As dead products are typically used to treat inflammatory acne
skin cells ans oil (sebum) accumulates/buils up in the and comedonal breakouts as well as scarring due to
Due to the fact that Tretinoin is UV (ultraviolet radiation) light blocked pore, the microcomedo enlarges and can collagen production. Still, tretinoin is effective against
retinoic acid, it is more potent and breaks down the collagen and become an open comedo, better known as a black head inflammatory as well as non-inflammatory acne.
results are seen within 6-8 weeks elastin fibers in the skin. These or a closed comedo better known as a white head.
as it does not need to go through the fibers form the connective tissue
oxidation process like retinol, in order that supports the skin. As this These 3 factors play a major role in the development of
to be converted to retinoic acid. layer breaks down, the skin acne:
becomes weaker and less 1. Too much sebum/oil gets produced
2. Follicular hyperkeratinisation
3. Acne-causing bacteria are present

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