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Formulation and evaluation of intimate hygiene wash containing active phytoconstituents

*
1 Konda Swathi

1 Sri Padamavathi Mahila Viswavidhyalayam, Tirupati, 517101, India.

* Corresponding author: kswathi84@yahoo.co.in

Abstract:

Yeast, bacteria, and fungi can all trigger vaginal infections. It stings and is unpleasant. If left untreated, they
may lead to complications that are deleterious to a person's health. Antimicrobials appear in a range of
chemical and natural forms. Antimicrobial resistance has grown substantially worse over the past 20 years
as a health concern. Utilizing in vitro investigations, the current study assessed the Phyllanthus niruri
methanolic extract's therapeutic potential against microbial communities vaginal infections. The active
components of the plant extract were used in Insilco molecular docking studies. Swiss adme prediction was
conducted for the constituents and molecular docking simulations were performed out by using Schrodinger
software. The Soxhlet apparatus has been used for extraction. Phytochemical examination has been
attempted to evaluate the constituents that are present in the plant extract. The active principle in a
pharmaceutical formulation is blended with additives in a multi-step operation that reflects PH, particle
size, polymorphism, particle size, and solubility to create the final, effective medical result. Plant extract
was used to create an emulsion and suspension. The bioactivity of various antibiotics is determined using
an antibiotic assay, often known as a biopotency assay. To assess the antibacterial activity of the plant
extract, this cup-and-plate method was used. This study educates you about the antimicrobial properties of
Phyllanthus niruri's active components and is significant to forthcoming investigators.

Keywords: Antimicrobials, Intimate hygiene wash, Plant extract, Phyllanthus niruri, active
phytoconstituents