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Effects of cholesterol in treatment of Hypertension

        -abnormalities of lipoprotein metabolism occur more frequently in patients with hypertension and
        hypercholesterolemia impairs endothelium-dependent relaxation long before the formation of atherosclerosis.(3)



        -The majority of cholesterol studies have focused on isolated peripheral vessels and there is a lack of
        information as to whether cholesterol effects systemic hemodynamics.



        -findings suggest that hypercholesterolemia is related to hyperreactivity to stress and this greater BP response to
        mental stress may contribute to the increased prevalence of hypertension in this population.



        -The present study also suggests that cholesterol levels are associated with BP; thus, lowering cholesterol may
        have a role in the overall control of BP.(4)

















        References


              •   (1)Larsen MK, Matchkov VV. Hypertension and physical exercise: The role of oxidative stress. Medicina. 2016
                 Feb;52(1):19-27.

              •   (2) Siegel WC, Blumenthal JA. The role of exercise in the prevention and treatment of hypertension. Annals of Behavioral
                 Medicine. 1991 Mar 1;13(1):23-30.

              •   (3)Creager MA, Gallagher SJ, Girerd XJet al. : L-Arginine improves endothelium-dependent vasodilation in
                 hypercholesterolemic humans. J Clin Invest 1992;90:1248–1253

              •   (4) Cohen RA, Zitnay KM, Haudenschild CCet al. : Loss of selective endothelial cell vasoactive functions caused by
                 hypercholesterolemia in pig coronary arteries. Circ Res 1988;63:903–910












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