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1st Int. Transborder Conf. of the Timor Island: Timor %u2013 Science without borderDili, 7-8 May 2025129Comparison of Serum Vitamin D Levels Between Arthralgia and NonArthralgia Groups Among Indoor Workers with Suspected Osteoarthritis Genu in Kupang City WorkersAnnisa N. Hasanah, Elisabeth L. S. Setianingrum, Teguh D. Nugroho and Su D. T.RanteFaculty of Medicine and Veterinary Science, Universitas Nusa Cendana*Corresponding author: annisanurulhasanah2003@gmail.com.AbstractOsteoarthritis (OA) is a degenerative joint disease characterized by pain and stiffness, commonly affecting the vertebrae, pelvis, knees, and ankles. Early symptoms include joint pain (arthralgia), which may be associated with vitamin D deficiency. Other risk factors include age, gender, obesity, and ergonomic conditions in the workplace. This research aims to reduce the risk of knee OA in workers and improve their overall health.The objective of this study was to compare serum vitamin D levels between workers with and without arthralgia in Kupang City who were suspected of having knee osteoarthritis (genu OA). This observational analytic study used a cross-sectional design and involved 46 indoor workers from Bureau of Statistics, Transport Department, and Department of Public Housing and Settlement Areas. The study included anamnesis, body mass index (BMI) measurement, evaluation of knee pain using the Visual Analogue Scale (VAS), and blood sample collection. Serum vitamin D levels were measured using the electrochemiluminescence immunoassay (ECLIA) method. Participants were selected through consecutive sampling, and data were analysed using the Independent T-test. All participants were women aged 18%u201359 years. Of the 46 respondents, 22 experienced knee joint pain (arthralgia), while 24 did not (nonarthralgia). A significant difference in serum 25-hydroxyvitamin D (25-OHD) levels was observed between the two groups (p = 0.000, p < 0.05). In the arthralgia group, the mean 25-OHD level was 17.2 %u00b1 2.94 ng/mL, with an average VAS score of 5.83, indicating moderate pain. In contrast, the non-arthralgia group had a mean 25-OHD level of 24.1 %u00b1 2.51 ng/mL and a VAS score of 0. In conclusion, there is a significant difference in serum vitamin D levels between arthralgia and non-arthralgia groups among workers in Kupang City, suggesting a potential link between vitamin D deficiency and knee joint pain.Keywords: Osteoarthritis (OA), joint pain (arthralgia), vitamin D deficiency, serum vitamin D levels, work ergonomics.