Page 71 - Sách năm 2022 - Fulltext - hieu final

EFFECACY OF ANTIMICROBIAL STEWARDSHIP IN PROPHYLACTIC

ANTIBIOTICS UTILIZATION IN CESAREAN SECTION AT DONG NAI

INTERNATIONAL HOSPITAL
ABSTRACT

Background: Caesarean section increases the risk of infection from 5 - 20 times more

than a vagina. The use of prophylactic antibiotics (PA) has also proven to reduce the risk of

infection in caesarean section and effective as the use of antibiotic antibiotics on selected
patients, which helped save costs and shorten the time of hospitalization . Therefore, the used

of PA in cesarean section was necessary in clinical practice.

Objective: Evaluation of the effectiveness of antimicrobial stewardship on cesarean
section at Dong Nai International Hospital

Methods: Retrospective cohort study on medical records of hospitalized patients from

October 1, 2016 to April 30, 2020, including 2 groups before the intervention (control group,
from October 1, 2016 - March 3, 2017) and after the intervention (intervention group, January

1, 2020 - April 30, 2020). General rationality was assessed based on six factors: justified use

or non-use of PA, antibiotic choice, timing of administration, route of administration, dose,
duration of administration.

Results: We have surveyed on 292 medical records control group and 287 medical

records intervention group, the main age group was 18-35, (85.4%) and the reason for cesarean

section was mainly abnormal because the mother accounts (52.3%). The general rationality of
used PA in cesarean section of control group were 0.0% and intervention group 86.1%

(p<0.001). This intervention had the most positive impact on icreasing the rate of “correct PA

choice” (p<0.001). There was no difference in the effect after discharge in both groups (from
99.7% in the control group and 97.9% in the intervention group, p=0.137).

Conclusion: The program of antimicrobial stewardsship, the overall compliance rate

with reasonable use of PA increased and the post-discharge status was similar in cesarean

section.
Keywords: Antibiotic prophylaxis, caesarean section, antimicrobial stewardship.

71