Page 6 - e-book QR - BIPOLAR DISORDER 2ND ED

QUICK REFERENCE MANAGEMENT OF BIPOLAR DISORDER (2ND EDITION)

Severe Avoid Avoid Avoid Max: 40 mg/day Not information Avoid 0.5 mg twice daily
HEPATIC IMPAIRMENT DOSE Moderate No dose adjustment No dose adjustment WITHOUT ascites:  dose by ~25% WITH ascites:  dose by ~50% Use with caution & consider dose reduction as it is metabolised primarily in the liver No dose adjustment N

Mild No dose adjustment No dose adjustment No dose adjustment

CrCl <30 ml/min Avoid <10: Caution* Caution use Avoid <50: Max: 80 mg/day <10: Avoid <10: Avoid
RENAL IMPAIRMENT DOSE CrCl 30 - 59 ml/min Initiate at lower dose No dose adjustment No dose adjustment No dose adjustment No dose adjustment No dose adjustment No dose adjustment No dose adjustment necessary 10 - <50: Initial: 1

CrCl 60 - 89 ml/min No dose adjustment No adjust- ment
RECOMMENDED ADULT MEDICATION DOSAGES FOR BIPOLAR DISORDER No dose adjustment No dose adjustment No dose adjustment 50 - <80: Initial: 3 mg OD Max: 6 mg OD 30 - 60: 50 - 75% of usual dose 1

USUAL DOSE RANGE PO: 900 - 1800 mg/day in divided doses. (Max dose: 1.8 g/day in 1 to 3 divided doses) PO: 1000 to 2000 mg/day (i.e. 20 - 30 mg/kg/day) (Max dose: 2500 mg/day or 60 mg/kg/day) PO: 100 - 400 mg/day in divided doses PO: 400 - 1600 m

MEDICATION MOOD STABILISERS Lithium Valproate Lamotrigine Carbamazepine ANTIPSYCHOTICS Aripiprazole Asenapine Cariprazine Haloperidol Lumateperone Lurasidone Olanzapine Paliperidone Quetiapine Risperidone weeks)

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