Page 227 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

• Uses: Flavouring agent in many pharmaceutical preparations

3
O SO Na
O

2Na SO + 2H O
3
2
2
2NaOH
SO Na
3

3- Diosphenol (Buchu Camphor) OH
• Occurrence: in Buchu leaf (Barosma betulina)
• Isolation: O
By cooling at -20 ºC
As soluble salt (+KOH) → acidify & extract with ether
• Properties:
Crystalline on cooling, colourless with camphor-like odour Diosphenol
Has phenol-like character “enolic”, so it form soluble enolate salt with dil KOH
• Identification:
Reduces Fehling’s & ammonical AgNO3 solution gives intense green colour with FeCl3
by formation of derivatives e.g. phenylurethane (with alcohol) or oxime (with ketone) with
definite m.p.
• Uses: Urinary tract antiseptic.

B) Bicyclic Terpene Ketones

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