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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(
EXAMPLES
1. The dissolution rate of the in is 5000
times faster than that of the free acid.
▪ Oral administration of the more rapidly dissolving sodium salt of
tolbutamide produced a very rapid decrease in blood sugar level.
▪ In contrast, the tolbutamide free acid produced a much slower rate of
decrease of blood sugar that was maintained over a longer period of
time.
2. The barbiturates are often administered in the form of sodium salts to achieve
a rapid onset of sedation.
3. NSAID (naproxen) was originally marketed as the free acid. However, the
sodium salt (naproxen sodium) is absorbed faster and is more effective
4. Conversely, strongly acidic salt forms of weakly basic drugs, for example
chlorpromazine hydrochloride, dissolve more rapidly in gastric and intestinal fluids
than do the free bases (e.g. chlorpromazine).
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