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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

CHAPTER SUMMARY

Glomerular filtration

• The kidneys receive approximately 25% of the cardiac output, or 1.2–1.5 L of blood

per minute via the renal artery.

• Approximately 10% of this volume (i.e. 120–150mL) is removed every minute as

it passes through the glomeruli of the kidneys.

Active tubular secretion

• In addition to glomerular filtration, certain drugs can also be secreted into kidney

tubules (e.g., dicloxacillin).

• Factors affecting tubular reabsorption

-Urine pH

-Urine flow rate

Other routes of excretion

Biliary, fecal, salivary , pulmonary , mammary , skin excretion

Frequently asked questions

1. What are the differences between Glomerular filtration and Active tubular

secretion?

2. What are the Other routes of excretion (discuss only three)?

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