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PharmD clinical pharmacy program            Level 3, Semester 2          Biopharmaceutics & Pharmacokinetics (PT608(


























             Plasma level–time curves for a drug that   Area under the plasma level–time curve

               exhibits  a  saturable  elimination  process.        versus  dose  for  a  drug  that  exhibits  a

               Curves A and B represent high and low                saturable  elimination  process.  Curve  A

               doses  of  drug,  respectively,  given  in  a        represents  dose-dependent  or  saturable

               single  IV  bolus.  The  terminal  slopes  of        elimination kinetics. Curve C represents

               curves  A  and  B  are  the  same.  Curve  C         dose-independent kinetics.

               represents      the     normal      first-order

               elimination of a different drug.






























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