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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(
Level C Correlation
Level C correlation is not a point-to-point correlation.
Level C correlation establishes a single-point relationship between a dissolution
parameter such as percent dissolved at a given time and a pharmacokinetic parameter
of interest such as AUC and C max.
Level C correlation is useful for formulation selection and development but has
limited application.
Multiple Level C correlation relates one or several pharmacokinetic parameters of
interest to the amount of drug dissolved at several time points of the dissolution profile.
General, if one can develop a multiple Level C correlation, then it may be feasible to
develop a Level A correlation.
A correlation between time required for a given amount of drug to be absorbed
and time required for the same amount of drug to be dissolved in vitro
(Three sustained-release aspirin products)
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