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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Calculation of Volume of Distribution

- The Vd is determined from the preinjected amount of the dose in the syringe and the

plasma drug concentration resulting immediately after the dose is injected.

=
( )

= ( )

Where,

X 0: The administered dose of a drug (for a drug injected IV, it is also the mass or

amount of drug in the body at time t=0)

(Cp) 0: The initial plasma concentration at time t=0

The plasma concentration against a time plot (semilogarithmic paper) following the

administration of three different IV bolus doses of the drug to a subject.

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