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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Frequently asked questions

 A 70-kg volunteer is given an IV dose of an antibiotic, The
C p were 1.2 and 0.3 mg/mL at 2 and 5 hr, respectively. What is the
t ½ for this drug, assuming first-order elimination kinetics?

ANSWER

✓ The Cp decreased from 1.2 to 0.3 mg/mL in 3 hrs
0
Log Cp= Log Cp −
2.3
( 3)
Log 0.3= Log 1.2−
2.3
= 0.462hr¯¹

½ = . = . = 1.5hr

.

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