Page 33 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed
P. 33
PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(
Compartment Models
A compartment is not a real physiologic or anatomic region but is considered as a
tissue or group of tissues that have similar blood flow and drug affinity.
Within each compartment, the drug is considered to be uniformly distributed.
Mixing of the drug within a compartment is rapid and homogeneous.
Organs and tissues in which drug distribution is similar are grouped into one
compartment.
The highly perfused organs (e.g., heart, liver, and kidneys) often have similar
drug distribution patterns, so these areas may be considered as one compartment.
The compartment that includes blood (plasma), heart, lungs, liver, and kidneys
is usually referred to as the central compartment or the highly blood-perfused
compartment or compartment 1.
The other compartment that includes the fat tissue, muscle tissue, and
cerebrospinal fluid is the peripheral compartment, which is less well perfused than
the central compartment or compartment 2.
32
