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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

CHAPTER SUMMARY

❖ Drug product performance is the release of the drug substance from the drug

product either for local drug action or for absorption into the plasma for systemic
drug activity.

❖Pharmacokinetics is the study movement of drugs in the body and includes the

kinetics of drug absorption, distribution, and elimination (ie, excretion and

metabolism).

❖ The quantitative measurement of drug concentrations in the plasma after dose

administration is important to obtain relevant data of systemic drug exposure.

❖ The plasma drug concentration versus time profile provides the basic data from

which various pharmacokinetic models can be developed that predict the time

course of drug action, relate the drug concentration to the pharmacodynamic effect

or adverse response, and enable the development of individualized therapeutic

dosage regimens and new and novel drug delivery systems.

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