Page 27 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

 MTC represents the drug concentration needed to just barely produce a toxic
effect.

3. Therapeutic range or therapeutic window

 The plasma or serum concentration range within which the drug is likely to

produce the therapeutic activity or effect.

 The range of plasma concentration between MEC and MSC.

 As long as the drug level is maintained within the therapeutic window, the
therapeutic effect of the drug is observed without side effects.

Onset of action

The time at which the administered drug reaches the therapeutic range and begins to

produce the effect.

Duration of action

The time span from the beginning of the onset of action up to the termination of

action.

Termination of action

The time at which the drug concentration in the plasma falls below the minimum

effective concentration (MEC).

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