Page 26 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Pharmacokinetic Parameters

Parameters Name Significance Key features

 Cmax Maximum The highest drug Cmax and Tmax are correlated and

plasma concentration was observed depend on how quickly the drug

concentration in plasma following enters into and is eliminated
administration. from the body

 Tmax Time at which The time at which the

Cmax is reached highest drug concentration

occurs.

 AUC Area under the The measure of total It represents the amount of

concentration- systemic exposure to the unchanged drug that has reached

time curve drug the systemic circulation and is
useful to define the

bioavailability of a drug

 Vd Volume of The apparent volume into It depends on binding to plasma

distribution which the drug is dissolved proteins and tissues and is useful
to correlate the drug

concentration in plasma with its

amount in the body

 t½ Half-life time in the time taken for the It is independent on the amount

the terminal concentration of a drug to of a drug in a body and is useful

phase reach 50% of its initial

concentration (i.e. the time
taken for a drug

concentration to reach half

of its initial value)

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