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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(
Using sigma minus method
▪ Plot log (Du - Du) versus time
▪ Evaluate k and t½ from slope.
Du
In your opinion, which method (the rate or sigma minus) is highly affected by the
fluctuation in the rate of drug elimination? and why?
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