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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Intravenous bolus administration

Monitoring drug in urine

Urinary drug excretion data may also be used for the calculation of the first-order
elimination rate constant (K).

A rectilinear plot of the amount of drug remaining in the blood and the amount of drug
.
eliminated in the urine with time following the administration of a drug as an IV bolus

=

Where,

➢Du: Amount of drug excreted unchanged in urine

➢ ke: Renal excretion rate constant, and

➢ DB: Amount of drug in body/ blood

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