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PharmD clinical pharmacy program            Level 3, Semester 2          Biopharmaceutics & Pharmacokinetics (PT608(










                  Determination of the Model Parameters



                   When time is large, because Ka ˃˃ K, e          –Kat    approaches zero,

                   Equation becomes:





































               The elimination half-life (t½) and elimination rate constant (K) can be obtained by

                  methods described earlier.

               From the terminal phase determine the elimination rate constant (K).








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