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                                            STUDY SUMMARY


                                                                         Safety/
      Year                   Author, Ref, Journal               Efficacy Tolerabi- Usability  Study  Supportive/ critical
                                                                          lity
           Boyle JE, Ghosh K, Gieser DK, Adamsons IA. Ophthalmo-
     1998                                                         x                          x          Supportive
           logy.
                                                                                           Meta-
     2012  Cheng JW, Cheng SW, Gao LD, Lu GC, Wei RL. PLoS One.   x                                     Supportive
                                                                                          analysis
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     2013  Duokopt ,Usability testing report for medical device -TIM-,              x        x          Supportive
           Transparence et Information du Médicament.

           Philippe Denis, Susana Duch, Enping Chen, Per Klyve,
     2020 Jesper Skov, Paıvi Puska, Carl Erb.European Journal of                    x                   Supportive
           Ophthalmology.

     2001  Harris A, et al. Am J Ophthalmol.                      x                          x          Supportive


           Hutnik C, Neima D, Ibrahim F, Scott R, Vaillancourt J, Haine
     2010                                                         x        x                 x          Supportive
           D, Sampalis JS, Bastien N, Foucart S. Clin Ophthalmol.

           Januleviciene I, Ehrlich R, Siesky B, Nedzelskiené I, Harris A.
     2009                                                         x                          x          Supportive
           Eur J Ophthalmol.

           Konstas AG, Quaranta L, Yan DB, Mikropoulos DG, Riva I, Gill
     2012                                                         x                          x          Supportive
           NK, Barton K, Haidich AB. Eye (Lond).

     2015  Kwon J, Heo J.H, Kim H.M, Song J.S. Korean J Ophthalmol.  x                       x          Supportive

           Leske, M. C., Wu, S. Y., Nemesure, B., Hennis, A. Ophthalmo-
     2002                                                         x                          x          Supportive
           logy.
           Manni G, Denis P, Chew P, Sharpe ED, Orengo-Nania S,
     2009 Coote MA, Laganovska G, Volksone L, Zeyen T, Filatori I,   x              x        x          Supportive
           James J, Aung T.  J Glaucoma.

     2008 Martínez A, et al. Clin Ther.                           x                          x          Supportive


     2010  Martınez A, Sanchez-Salorio M. Acta Ophthalmol.        x                          x          Supportive

           Pajic B, Pajic-Eggspuehler B, Häfliger IO. Curr Med Res
     2010                                                         x                          x          Supportive
           Opin.

           Pinto LA, E. Vandewalle, L. Gerlier, I. Stalmans. Ophthalmo-
     2013                                                                  x                 x          Supportive
           logica.

           Renieri G, Führer K, Scheithe K, Lorenz K, Pfeiffer N, Thieme
     2010                                                         x        x                 x          Supportive
           H. Pharmacol Ther.

           Shedden A, Adamsons IA, Getson AJ, Laurence JK, Lines CR,
     2010                                                         x        x                 x          Supportive
           Hewitt DJ, Ho TW. Graefes Arch Clin Exp Ophthalmol.

                                                      Table 1 - Study summary


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