Page 7 - DUOKOPT BIBLIOBOOK

EFFICACY

STUDY CLAIMS

Authors, title, Journal, Year, Ref Study type / Claims

Usability Testing Report for Medical Device. TIM (Transparence et Information du
®
Médicament) The innovative bottle Easygrip is easy to use for patients.
(According to ISO IEC 62366:2007) Jun 2013.
Usability Testing Report for Medical Device.
®
®
®
TIM Transparence et Information du Médicament. (According to ISO IEC The new bottle Easygrip is easier to use compared to COMOD and Control gripTM .
62366:2007) Jun 2013.
European real-world data about the use of a new delivery system containing a
®
®
preservative-free multi-dose glaucoma treatment . The New Preservative-Free Multidose Easygrip is easy to use by glaucoma patients.
Denis P; et al. European Journal of Ophthalmology.2020 May;0(0) 1-8.
A randomized trial comparing the dorzolamide-timolol combination given twice Dorzolamide-Timolol fixed combination is more efficient in lowering IOP then Dorzola-
daily to monotherapy with timolol and dorzolamide. mide on Timolol administered as monotherapy.
Boyle JE, et al. Ophthalmology. 1998 Oct;105(10):1945-51.
The safety and efficacy of brinzolamide 1% timolol 0.5% fixed combination versus Brinzolamide-Timolol and Dorzolamide-Timolol fixed combination provide the same IOP
dorzolamide 2% timolol 0.5% in patients with OAG or OH. lowering efficacy.
Manni G, et al. J Glaucoma. 2009 Apr-May; 18(4):293-300.
Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination
compared with the brimonidine/timolol-fixed combination in primary open-angle Dorzolamide-Timolol fixed combination is more efficient on 24-hour IOP than Brimoni-
glaucoma. dine-Timolol fixed combination.
Konstas AG, et al. Eye (Lond). 2012 Jan; 26(1):80 7.
Intraocular pressure-lowering effects of commonly used fixed-combination drugs Among fixed combinations with timolol, Dorzolamide-Timolol has a similar efficacy on
with timolol: a systematic review and meta-analysis. IOP compared to Brimonidine and Brinzolamide combinations with Timolol.
Cheng JW, et al. PLoS One. 2012;7(9):e45079.
Effect of Dorzolamide Timolol Combination Versus Timolol 0.5% on Ocular Bloo- Dorzolamide-Timolol fixed combination reduces IOP and increases ocular
dflow in Patients With Primary Open-angle Glaucoma. blood flow compared to Timolol.
Harris A, et al. Am J Ophthalmol 2001; 132:490–495.
Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure,
retrobulbar blood flow, and the progression of visual field damage in patients with Dorzolamide-Timolol fixed combination shows a reduction IOP even in the long term.
primary open-angle glaucoma: a single-center, 4-year, open-label study.
Martínez A, et al. Clin Ther. 2008 Jun; 30(6):1120-34.
Visual function, optic nerve structure, and ocular blood flow parameters after 1 1-Year treatment of Dorzolamide-Timolol fixed combination permits IOP reduction, a
year of glaucoma treatment with fixed combinations. stable visual function and a higher optic nerve perfusion.
Januleviciene I, et al. Eur J Ophthalmol. 2009 Sep-Oct;19(5):790-7.
Predictors for visual field progression and the effects of treatment with dorzola-
mide 2% or brinzolamide 1% each added to timolol 0.5% in primary open-angle Treatment with Dorzolamide-Timolol reduces the risk of visual field progression.
glaucoma.
Martinez A, et al. Acta Ophthalmol. 2010: 88: 541–552. 3.
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed
combinations upon intraocular pressure and progression of visual field damage in Dorzodamide-Timolol fixed combination in long-term treatment is effective to reduce
primary open-angle glaucoma. IOP and in preventing visual field progression.
Pajic B, et al. CMRO. 2010 Sep;26(9):2213-9.
Comparison of Cytotoxic Effects on Rabbit Corneal Endothelium between Preser- Preservative-free Dorzodamide-Timolol has a safer profile than the preserved fixed
vative-free and Preservative-containing Dorzolamide/ timolol. combination.
Kwon J, et al. Korean J Ophthalmol 2015;29(5):344-350
Comparison of the efficacy and tolerability of preservative-free and preser-
vative-containing formulations of the dorzolamide/timolol fixed combination Preservative-free Dorzolamide-Timolol has a similar efficacy as the preserved fixed com-
(COSOPT™) in patients with elevated intraocular pressure in a randomized clinical bination but with a better tolerance.
trial.
Shedden A, et al. Graefes Arch Clin Exp Ophthalmol. 2010 Dec;248(12):1757-64.
Efficacy and tolerability of preservative-free eye drops containing a fixed combi- Switching from preserved treatment to unpreserved Dorzolamide-Timolol fixed combi-
nation of dorzolamide and timolol in glaucoma patients. nation improves local tolerability.
Renieri G, et al. J Ocul Pharmacol Ther. 2010 Dec;26(6):597-603.
Tolerability and effectiveness of PF dorzolamide-timolol (PF COSOPT) in patients In newly diagnosed patients, PF Dorzolamide-Timolol combination does not increase
with open-angle glaucoma or ocular hypertension. eye discomfort and contributes to both high patient's and ophthalmogist's satisfaction.
Hutnik C, et al. Clin Ophthalmol. 2010 Jul 21;4:581-90.
Improvement in glaucoma patients quality of life by therapy switch to preservative Switching from preserved to preservative-free Dorzolamide-Timolol combination impro-
free timolol/dorzolamide fixed combination (The CosoptUD Study Group) ves ocular surface symptoms and patient's vision related to quality of life.
Pinto LA, et al. Ophthalmologica - Published on line December 2013.
Second-line therapy with dorzolamide/timolol or latanoprost/timolol fixed
combination versus adding dorzolamide/timolol fixed combination to latanoprost Tritherapy with latanoprost in addition to Dorzolamide-Timolol combination provides an
monotherapy. additionnal 24h IOP reduction than Dorzolamide-Timolol alone.
Konstas AG, et al. Br J Ophthalmol. 2008 Nov;92(11):1498-502.

Table 2 - Study claims

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